Differential Expression of CD148 on leucocyte subsets in inflammatory arthritis
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چکیده
Differential Expression of CD148 on leucocyte subsets in inflammatory arthritis Arthritis Research & Therapy 2013, 15:R108 doi:10.1186/ar4288 Richa K Dave ([email protected]) Amy J Naylor ([email protected]) Rachel Bayley ([email protected]) Stephen P Young ([email protected]) Debbie L Hardie ([email protected]) Oliver Haworth ([email protected]) David A Rider ([email protected]) Andrew D Cook ([email protected]) Christopher D Buckley ([email protected]) Stuart Kellie ([email protected])
منابع مشابه
Differential expression of CD148 on leukocyte subsets in inflammatory arthritis
INTRODUCTION Monocytic cells play a central role in the aetiology of rheumatoid arthritis, and manipulation of the activation of these cells is an approach currently under investigation to discover new therapies for this and associated diseases. CD148 is a transmembrane tyrosine phosphatase that is highly expressed in monocytes and macrophages and, since this family of molecules plays an import...
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CD148 is a receptor-like protein-tyrosine phosphatase known to inhibit transduction of mitogenic signals in non-hematopoietic cells. Similarly, in the hematopoietic lineage, CD148 inhibited signal transduction downstream of T cell receptor. However, it also augmented immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src family kinases (SFK). Accord...
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تاریخ انتشار 2013